Thioridazine chloridate
thioridazine hydrochloride
CAS: 130-61-0
Molecular Formula: C21H27ClN2S2
Thioridazine chloridate - Names and Identifiers
Thioridazine chloridate - Physico-chemical Properties
| Molecular Formula | C21H27ClN2S2 |
| Molar Mass | 407.04 |
| Density | 1.1227 (rough estimate) |
| Melting Point | 158-1600C |
| Boling Point | 230°C (rough estimate) |
| Flash Point | 265.7°C |
| Water Solubility | Soluble in water (75 mM), DMSO (100 mM), chloroform, ethanol, and methanol. |
| Solubility | H2O: soluble250 mg plus 5 ml of solvent, clear, colorless to faintly yellow |
| Vapor Presure | 9.65E-11mmHg at 25°C |
| Appearance | White to off-white solid |
| Color | White to Almost white |
| Maximum wavelength(λmax) | ['317nm(EtOH)(lit.)'] |
| Merck | 14,9359 |
| Storage Condition | 2-8°C |
| Sensitive | Light Sensitive & Hygroscopic |
| Refractive Index | 1.5610 (estimate) |
| Use | Suitable for acute schizophrenia, bipolar disorder, menopausal psychosis, neurological depression, etc |
Thioridazine chloridate - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9/PG 3 |
| WGK Germany | 3 |
| RTECS | SP2275000 |
| HS Code | 2934302300 |
| Hazard Class | 9 |
Thioridazine chloridate - Standard
Authoritative Data Verified Data
This product is 10-[2-(l-methyl-2-piperidinyl) ethyl]-2-methylthiophenothiazine hydrochloride. The content of C21H26N2S2 • HCl shall not be less than 99.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
Thioridazine chloridate - Trait
Authoritative Data Verified Data
- This product is white or white crystalline powder; Slightly odor.
- This product is soluble in chloroform, soluble in ethanol or water, almost insoluble in ether.
melting point
The melting point of this product (General rule 0612) is 159~165°C, and the melting distance shall not exceed 2°C.
Last Update：2022-01-01 15:34:19
Thioridazine chloridate - Differential diagnosis
Authoritative Data Verified Data
- take about 5mg of this product, add 2ml sulfuric acid to dissolve, the solution shows blue.
- take this product and add ethanol to make a solution containing about 8ug per lml, and measure by UV-Vis spectrophotometry (General 0401), there is maximum absorption at wavelengths of 264nm and 315nm.
- The infrared absorption spectrum of this product should be consistent with the control spectrum (Spectrum set 1034).
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 15:34:19
Thioridazine chloridate - Exam
Authoritative Data Verified Data
acidity
take 0.20g of this product, add 20ml of water to dissolve, and then measure it according to law (General rule 0631). The pH value should be 4.2~5.2.
Related substances
operation in the dark. Take this product, precision weigh, add methanol to dissolve and quantitatively dilute to make a solution containing about 250ug thiolidaphenium hydrochloride per 1 ml, as a test solution; Take an appropriate amount of precision, A solution containing about 1.25ug of thioridazine hydrochloride in 1 ml was prepared by dilution with methanol as a control solution. According to the test of high performance liquid chromatography (General 0512), silica gel bonded with eighteen alkyl silane was used as the filler; Triethylamine-acetonitrile-water (2:400:600) was used as the mobile phase A, the mobile phase B was triethylamine-acetonitrile (2:1000); The flow rate was 1.0 ml per minute, and the linear gradient elution was carried out according to the following table; The detection wavelength was 275mn. 20 u1 of each of the control solution and the test solution were accurately measured and injected into the human liquid chromatograph respectively, and the chromatogram was recorded. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.2 times (0.1%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (0.5%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of burning and submerging shall be inspected according to law (General Rule 0 8 2 1 second law) and shall not contain more than 10 parts per million of heavy metals.
Last Update：2022-01-01 15:34:20
Thioridazine chloridate - Content determination
Authoritative Data Verified Data
take this product about 0.3g, precision weighing, add anhydrous glacial acetic acid-acetic acid (1:l ) 80ml to dissolve, according to the potential titration method (General 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml perchloric acid titration solution (0.1 mol/ L) corresponds to 40.70mg of C21H26N2S2 · HCl.
Last Update：2022-01-01 15:34:21
Thioridazine chloridate - Category
Authoritative Data Verified Data
antipsychotics.
Last Update：2022-01-01 15:34:21
Thioridazine chloridate - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 15:34:21
Thioridazine chloridate - Thioridazine hydrochloride tablets
Authoritative Data Verified Data
This product contains thioridazine hydrochloride (C21H26N2S2 • HCl) should be 93.0% ~ 107.0% of the label.
trait
This product is sugar-coated tablets, white or almost White after removing the coating.
identification
- take an appropriate amount of fine powder of this product (about 5mg equivalent to thioridazine hydrochloride), add 5ml of sulfuric acid to dissolve, and place it for 5 minutes to show a dark blue color.
- the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at a wavelength of Nm.
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
examination
- related substances, protected from light. Take this product, precision weighing, and methanol dissolved and quantitative dilution of thioridazine hydrochloride in about 250ug per lml solution, as a test solution. An appropriate amount of the test solution was accurately taken and diluted with methanol to prepare a solution containing about 1.25ug of thioridazine hydrochloride per 1 ml as a control solution. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.5% ) , the sum of each impurity peak area shall not be greater than 2 times (1.0%) of the main peak area of the control solution.
- dissolution rate protected from light. Take this product, according to the dissolution and release determination method (General rule 0931 The first method), with 0.lmol/L hydrochloric acid solution 1000ml as the dissolution medium, the rotation speed is 100 rpm, according to the law operation, after 45 minutes, 10ml of the solution was taken, filtered, and the appropriate amount of the filtrate was accurately taken and diluted with the dissolution medium to prepare a solution containing about 5ug per 1 ml. The absorbance was measured at a wavelength of 0401 NM according to ultraviolet-visible spectrophotometry (General rule 913), and the elution amount of each tablet was calculated as the absorption coefficient of C21H26N2S2 · HCl was. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Triethylamine-acetonitrile-water (1:850:150) as mobile phase; The detection wavelength was 264nm.
- The assay was operated in the dark. Take 20 tablets of this product, remove the sugar coating, precision weighing, fine, precision weighing take appropriate amount, add methanol to dissolve and make a solution containing thioridazine hydrochloride 100ug per 1 ml, as a test solution; in addition, an appropriate amount of thioridazine hydrochloride reference substance was accurately weighed and prepared by the same method as the reference solution. 20 u1 of each of the reference solution and the test solution were accurately measured and injected into the human liquid chromatograph respectively, and the chromatogram was recorded. According to the external standard method to calculate the peak area, that is.
category
Same as thioridazine hydrochloride.
specification
(l )25mg (2)50mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 15:34:22
Supplier List
Featured ProductsSpot supply
Product Name: Thioridazine Hydrochloride Visit Supplier Webpage Request for quotationCAS: 130-61-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Thioridazine hydrochloride Request for quotationCAS: 130-61-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Thioridazine hydrochloride Visit Supplier Webpage Request for quotationCAS: 130-61-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Thioridazine Visit Supplier Webpage Request for quotationCAS: 130-61-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Thioridazine hydrochloride Visit Supplier Webpage Request for quotationCAS: 130-61-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Thioridazine Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 130-61-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 130-61-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Thioridazine Hydrochloride Visit Supplier Webpage Request for quotationCAS: 130-61-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: Thioridazine hydrochloride Request for quotationCAS: 130-61-0
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Thioridazine hydrochloride Visit Supplier Webpage Request for quotationCAS: 130-61-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Thioridazine Visit Supplier Webpage Request for quotationCAS: 130-61-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Thioridazine hydrochloride Visit Supplier Webpage Request for quotationCAS: 130-61-0
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: Thioridazine Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 130-61-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
CAS: 130-61-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
Thioridazine chloridate
Iron(Ⅱ) sulfate
(Z)-Rose oxide
35932-39-9
化合物RG 13022
AKOS B029445
402-66-4
6-AMINO-O-CRESOL
339575-20-1
Iron(Ⅱ) sulfate
(Z)-Rose oxide
35932-39-9
化合物RG 13022
AKOS B029445
402-66-4
6-AMINO-O-CRESOL
339575-20-1